What E45 cream is used for? E45 cream has been clinically proven to treat and soothe dry, itching, flaking, chapped, rough and calloused skin, sunburn and detergent hands. Non greasy formula leaves skin soft & relieved. E45 cream is also for more serious dry skin conditions such as eczema, dermatitis, ichthyosis and certain dry cases of psoriasis. Perfume free - dermatologically tested.