The active ingredient benzydamine hydrochloride is a non-steroidal anti-inflammatory drug. What Difflam Oral Spray is and what it is used for Difflam Oral Spray contains the active substance benzydamine hydrochloride and belongs to a group of medicines called non-steroidal anti-inflammatory drugs or NSAIDs. Difflam Oral Spray works by stopping pain and swelling (inflammation). It is used to treat many painful conditions of the mouth or throat including: • Mouth ulcers • Sore throat • Discomfort associated with dentures or dental work. Other medicines and Difflam Oral Spray Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.