Benadryl NaturEase is a nasal spray that uses 100% natural ingredients which provides an effective form of allergy relief as well as soothing irritation. It will also clean the inside of your nose and rid it of any mucus-trapped allergins within. The active ingredient in this nasal spray is Ectoin. Ectoin is a natural ingredient taken from microorganisms that survive in extreme environments, such as geysers or lakes.